pitt

Center for Translational and International Hematology

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute
University of Pittsburgh

 

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Vascular Medicine Institute
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Center for Translational and International Hematology
412-648-9427

RESEARCH PROJECTS

Organ damage in sickle cell disease study (ORDISS)

ORDISS is a longitudinal observational study of organ dysfunction in individuals with sickle cell disease. The study seeks to identify early biochemical biomarkers of organ damage in a newborn cohort of children with SCD in the Komfo Anokye Teaching Hospital in Kumasi. Ghana. It involves collaboration with Hematologists, Pediatricians and Epidemiologist in the Kwame Nkrumah University of Science and Technology, Ghana, and the Sickle Cell foundation of Ghana. The study will establish a bio-repository at the Kumasi Collaborative Center for Research in Tropical Medicine to facilitate large-scale genotype-phenotype studies to identify genetic signatures of organ damage in sickle cell disease.

Pulmonary complications in pregnancy in sickle cell disease (PUCS)

The goal of this study is to define the role of edemagenic growth factors in the development of pulmonary complications, including acute chest syndrome (ACS) in pregnant women who have sickle cell disease. This study is being conducted in collaboration with a team of hematologists, obstetricians, pathologists and radiologist at the Korle Bu Teaching Hospital in Accra, Ghana and at Vanderbilt University. The study will establish a repository of postmortem lungs of cases of acute chest syndrome in pregnant women to facilitate histological changes associated with the condition.

Relative hypertension in sickle cell disease

The goal of this project is to define the prevalence of systemic hypertension in one of the largest adult sickle cell disease clinics in the world, at the Center for Clinical Genetics, Korle Bu Teaching Hospital in Accra. This study is being conducted with a team of Hematologists, Community Physicians and Clinical Psychologists in Ghana, US and in UK. A major objective of this study is to prepare the site in Ghana to participate in multi-center clinical trials of new agents in sickle cell disease.