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Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Pilot Project Program in Hemostasis and Vascular Biology (P3HVB)

The VMI Pilot Project Program in Hemostasis and Vascular Biology (P3HVB) is intended to attract investigators new to the general areas of hemostasis and vascular biology by seeding innovative and translational research projects that have the potential to open new avenues for critical research in the general areas of:

• Transfusion medicine
• Transfusion related acute lung injury (TRALI)
• Hemostasis and platelet biology, especially as focused on the integration of the roles of red cells, platelets, and hemostatic factors
• Hemophilia
• Small pilot clinical trials in above areas or vascular biology

The program will support grants of $25,000 for one year duration. Applications for new projects may request up to $25,000. On an annual basis, approximately $250,000 will be available for new awards. If a previously awarded project is successful in demonstrating that the area of research is important and innovative, the investigator may apply for competitive renewals.

University of Pittsburgh faculty members at the levels of assistant/research assistant professor, associate/research associate professor, and professor/research professor are eligible to apply as principal investigators. Instructors, fellows, and postdoctoral researchers may also apply as principal investigators if they can demonstrate a track record of research success, if there is a research mentoring plan from a qualified faculty member at the rank of assistant professor (not research track) or higher, and if there is a commitment from the faculty member in whose laboratory the instructor/fellow/postdoctoral researcher works that all necessary laboratory resources will be available for the proposed project. Applicants are encouraged to collaborate with VMI faculty on their projects.

APPLICATION PROCESS

The next receipt date is 5pm on March 15th, 2017.

Detailed information about the P3HVB and application instructions can be found HERE.


Awarded Grants

ACTIVE
  PI TITLE OF PROJECT SPONSOR STATUS
  Bates Vascular development and blood flow in normal and FGF receptor mutant bladders HCWP Active
  Buland Novel Biosynthesis of Lipid Mediators and their effects on Pulmonary Endothelium in ALI ITxM Active
  Chen MiR-34a regulation of tetrahydrobiopterin in angiogenesis ITxM Active
  Dorritie Development of a joint pediatric sickle cell allogeneic hematopoetic stem cell transplantation program: Innovation, Research, and High Quality Patient Care ITxM Active
  Gomez The goal of glycocalyx shedding and platelet adhesion in sepsis-induced microvascular dysfunction HCWP Active
  Jeyabalan Asymmetric Dimethylarginine, Arginase and Nitric Oxide in the Prediction and Pathogenesis of Preeclampsia ITxM Active
  Kass TGFB regulates expression of the relaxin receptor RXFP1 in Pulmonary Arterial Hypertension HCWP Active
  Lee Role of Red Cell Microparticles in Altering Innate Immune Response Following Transfusion ITxM Active
  Leeper Rapid thromboelastography (TEG) in pediatric trauma: Delineation and management of trauma-induced coagulopathy HCWP Active
  Mason PET imaging of the vaso-occlusive crisis of sickle cell disease HCWP Active
  Neal Platelet derived microparticles promote post-traumatic deep vein thrombosis formation HCWP Active
  Nouraie Risk of 30-day readmission among sickle cell disease patients, application of electronic medical record ITxM Active
  Patel Using electronic health records to assess the impact of obstructive sleep apnea on risk of incident pulmonary hypertension ITxM Active
  Rosano Neurovascular Signature of Accelerated Cognitive Impairment in Adult Patients with Sickle Cell Disease ITxM Active
  Sims-Lucas The renal microvasculature is highly sensitive to hyperglycemia ITxM Active
  Steinman Cell Cycle Proteins as Novel Modulators of Platelet Function HCWP Active
  Weisz VinDCate: Vitamin D in sickle cell patient ITxM Active
COMPLETED
  PI TITLE OF PROJECT SPONSOR STATUS
  Ahmad The Role of Platelet Gene Expression in the Pathogenesis of Pulmonary Arterial Hypertension HCWP Completed
  Badylak / Gilbert CD47 blockade enhances angiogenesis in decellularized organs ITxM Completed
  Bauer Complement Activation and Thrombosis in Pulmonary Hypertension* HCWP Completed
  Bauer Cross talk between TLR4 and the complement system contributes to the pathogenesis of pulmonary hypertension HCWP Completed
  Bayir / Kim-Campbell Cardiopulmonary bypass and organ dysfunction: association with hemolysis and cell-free hemoglobin ITxM Completed
  Belfer Exploratory studies of psychophysical pain phenotyping and genetic variability in children with sickle cell disease ITxM Completed
  Bisello EBP50 and atherosclerosis HCWP Completed
  Bodnar Modulation of Endothelial Cell Function - Regulation by Platelet Activation HCWP Completed
  George HIV Nef and Src Kinase Signaling in HIV-Associated Pulmonary Arterial Hypertension HCWP Completed
  Hughan An Open-Label Study of Oral Combination of Nitrite and Nitrate in Adults with Metabolic Syndrome and Hypertension ITxM Completed
  Kelley Storage-Induced Hemolysis of Packed Red Blood Cells Results in Direct and Indirect ROS Production and NO Inactivation HCWP Completed
  Khandhar The Study of Pulmonary Hypertension in Patients with Left Heart Failure Utilizing Novel Vascular Biology Techniques HCWP Completed
  Kim Regulation of Platelet Biology and Thombosis by Histone Deacetylases HCWP Completed
  Lee Red Cell Microparticles in Transfusion-Related Lung Inflammatory Injury ITxM Completed
  McLaughlin
/ Kaynar
Regulation of Endothelial Function by Coagulation Proteases in Sepsis ITxM Completed
  McVerry The Role of Endothelial Dysfunction in Transfusion Related Acute Lung Injury ITxM Completed
  McVerry Interaction between Nox2 and eNOS contributes to pulmonary vascular dysfunction in acute lung injury ITxM Completed
  O'Donnell Impaired vascular blood flow to skeletal muscle in hyperglycemic sepsis ITxM Completed
  Ragni Phase II Biologic Effects Study of Recombinant Interleukin-11 (rhiL-11, Neumega®) in Subjects With Moderate or Mild Hemophilia A, or Von Willebrand Disease Unable to Use DDAVP HCWP Completed
  Ragni Thrombin generation and hemomstasis in the international immune tolerance study: ITI TGT Substudy HCWP Completed
  Rojas Modification of perfusion solution to improve the quality of ex vivo human lungs HCWP Completed
  Sims-Lucas Determining the role of stromally derived endothelium during organogenesis ITxM Completed
  Tillman Depletion of Circulating Progenitors to Prevent Vascular Restenosis HCWP Completed
  Tofovic Adenosine Deaminase - Adenosine Pathway in Hemolysis-Associated Pulmonary Hypertension HCWP Completed
  Yang Patient-Specific Induced Pluripotent Stem Cells as a Model for Inherited Pulmonary Arterial Hypertension ITxM Completed


*
March 2012 - Dr. Eileen Bauer was awarded the Entelligence Young Investigator Award in pulmonary vascular disease. Her submission was based on work funded by this VMI P3HVB grant.