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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Marta Bueno Fernandez, PhD

 

marta bueno phd

 

Marta Bueno, PhD

Research Assistant Professor of Medicine, Division of PACCM

E1200-24B BST
200 Lothrop Street
Pittsburgh, PA 15261

Phone: 412-624-2132
Fax: 412-648-9009
Email: mbueno@pitt.edu

  @mbuenof

Mora Lab

   

Bio

Dr. Bueno received her degree in Biochemistry in 2000 from the University of Zaragoza (Spain). She was awarded an Erasmus Fellowship to join the Bioenergetics and Microbiology Laboratory at University of Geneva (Switzerland) to work with Dr. François Barja and Dr. Reto Strasser on the effects of the pesticide lindane on the photosynthetic apparatus from the cyanobacterium Anabaena and its ferredoxin‐ NADP+ reductase. In 2006, she earned her PhD in Biochemistry at the University of Zaragoza (Spain) with the thesis "Stability and stabilization of proteins using Anabaena PCC7119 apoflavodoxin as a model" under the supervision of Dr. Javier Sancho (awarded with the 2007 Outstanding Thesis Award by the University of Zaragoza). The same year she moved to the United States to join the lab of Dr. Carlos Camacho at the Department of Computational Biology in the University of Pittsburgh. Her work there focused on the development of new protein scoring functions and the implementation of drug discovery techniques. Her study on the development of new antiviral compounds for kidney transplant patients, in collaboration with Dr. Parmjeet Randhawa (Division of Transplant Pathology, UPMC), earned Dr. Bueno the 2007 Thomas E. Starzl Postdoctoral Fellowship in Transplantation Biology. She joined the Vascular Medicine Institute in 2010 to work with Dr. Ana Mora.

Research Interests

Idiopathic Pulmonary Fibrosis (IPF) is a fatal and progressive lung disease, characterized by progressive scarring of the lung. IPF prevalence dramatically increases with age, and aging is a known risk factor for IPF. However, there is limited understanding in the mechanisms involved in the increased vulnerability of the aging lung to develop lung fibrosis. Under Dr Mora’s mentoring, Dr Bueno’s published findings were pioneered to identify alterations in mitochondrial homeostasis in the aging type alveolar epithelial cell (AECII) as a critical component of the pathogenesis of IPF.  Currently, our studies are extending to other diseases characterized by abnormal tissue repair and exaggerated remodeling, including pulmonary hypertension (PH).

Key Publications

Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, Corey C, Herazo-Maya JD, Sembrat J, Lee JS, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015 (PMID: 25562319)

Bueno M, Wang J, Mora AL, Gladwin MT. Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics. Antioxid Redox Signal. 2013 (PMID: 22871207)

Torres-González E, Bueno M, Tanaka A, Krug LT, Cheng DS, Polosukhin VV, Sorescu D, Lawson WE, Blackwell TS, Rojas M, Mora AL. Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. Am J Respir Cell Mol Biol. 2012 (PMID: 22227563)

Randhawa P, Zeng G, Bueno M, Salgarkar A, Lesniak A, Isse K, Seyb K, Perry A, Charles I, Hustus C, Huang M, Smith M, Glicksman MA. Inhibition of large T antigen ATPase activity as a potential strategy to develop anti-polyomavirus JC drugs. Antiviral Res. 2014 (PMID: 25453344)

Zheng G, Bueno M, Camacho CJ, Randhawa PS. Validation of BKV Large T-antigen ATP-binding site as a target for drug discovery. Antiviral Res. 2008 Dec 11. (PMID: 19084558)

Bueno M, Temiz NA, Camacho CJ. Novel modulation factor quantifies the role of water molecules in protein interactions. Proteins. 2010. In Press. (DOI: 10.1002/prot.22805)

Bueno M, Camacho CJ & Sancho J. SIMPLE estimate of the free energy change due to aliphatic mutations: Superior predictions based on first principles. Proteins (2007), 68: 850-862. (PMID: 17523191)

Bueno M, Ayuso-Tejedor S & Sancho J. Do proteins with similar folds have similar transition state structures? A diffuse transition state of the 169 residue apoflavodoxin. J. Mol. Biol. (2006), 359: 813-824. (PMID: 16647718)

Pubmed link