Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Laura M. De Castro, MD, MHSc


Laura De Castro


Laura De Castro, MD

Associate Professor of Medicine,
Division of Hematology/Oncology

5150 Centre Avenue, Fl 5
Pittsburgh, PA 15232

Phone: 412-648-6575
Email: decastrolm@upmc.edu



Laura M. De Castro MD, MHSc, is an Associate Professor of Medicine, Director of Benign Hematology for the Institute for Transfusion Medicine and UPMC Cancer Center, and Director of Clinical Translational Research for the Sickle Cell Disease Research Center of Excellence. In addition, she is a hematologist specializing in sickle cell disease and other hemoglobinopathies. Dr. De Castro also serves as Clinical Director of the Benign Hematology Program at UPMC, and works to expand clinical programs in hemostasis and thrombosis.

Dr. De Castro received her medical degree from the Universidad Autónoma de Santo Domingo in the Dominican Republic. She completed her Internal Medicine Residency at the Montefiore Medical Center, Albert Einstein School of Medicine in New York, and her hematology/oncology fellowship at Yale University in New Haven, CT.

Before coming to the University of Pittsburgh in 2013, Dr. De Castro spent 15 years as the Clinical Director of the Duke Adult Sickle Cell Center at Duke University.


De Castro L, Jonassaint J, Graham F, Ashley-Koch AE, and Telen MJ. (2008) Pulmonary Hypertension in SS, SC and Sβ Thalassemia: Prevalence, Associated Clinical Syndromes and Mortality. AJH. 83(1):19-25.

Eyler CE, Jackson T, Elliott , De Castro L, Jonassaint J, Ashley-Koch AE, and Telen MJ (2008) β2-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion BJH. 141 (1) , 105–108.

Zennadi R., De Castro, L.M., Eyler CE, Xu K.,  Ko M., Telen MJ. (2008) Role and Regulation of Sickle     Red Cell Interactions with Other Cells: ICAM-4 and Other Adhesion Receptors Transfusion Clinique et Biologique. 15(1-2):23-8.

Ataga KI. Smith WR. De Castro LM. Swerdlow P. Saunthararajah Y. Castro O. Vichinsky E. Kutlar A.,Stocker JW. ICA-17043-05 Investigators. (2008)  Efficacy and safety of the Gardos channel blocker, senicapoc    (ICA-17043), in patients with sickle cell anemia. Blood. 111(8):3991-7, Apr 15.

Ashley-Koch AE. Elliott L. Kail ME. De Castro LM. Jonassaint J. Jackson TL. Price J. Ataga KI. Levesque MC. Weinberg JB. Orringer EP. Collins A. Vance JM. Telen MJ. (2008) Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood. 111(12):5721-6, Jun 15.

Villers, MS, Jamison MG, De Castro, LM and James AH (2008) Morbidity associated with sickle cell disease in pregnancy. American Journal of Obstetric and Ginecology. 199(2):125.e1-5.

Adam, S,  Jonassaint J, Kruger , H, Kail, M, Orringer, E.P., Eckman JR,  Ashley-Koch AE, Telen MJ and De Castro, LM (2008) Surgical and Obstetric Outcomes in Adults with Sickle Cell Disease" American Journal of Medicine”, The American Journal of Medicine, 121,(10), Pgs. 916-921.

Ballas, S, McCarthy, W., De Castro, L et al (2009) Exposure to Hydroxyurea and Pregnancy Outcomes in Sickle Cell Disease. JNMA, 101 (10), pgs 1046-51.

Brittain JE. Hulkower B. Jones SK. Strayhorn D. De Castro L. Telen MJ. Orringer EP. Hinderliter A. Ataga KI. (2010) Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood. 115(10):2014-20.

Fitzhugh, CD, Lauder N, Jonassaint JC, Telen MJ, Zhao, X, Wright, EC, Gilliam, FR, and De Castro, LM (2010) Cardiopulmonary Complications Leading to Premature Deaths in Adult Patients with Sickle Cell Disease.  AJH 85(1) pgs 36-40

Jonassaint CR. Jonassaint JC. Stanton MV. De Castro LM. Royal CD. (2010) Clinical and sociodemographic factors predict coping styles among adults with sickle cell disease. J Nat Med Assoc. 102(11):1045-9, Nov.

Vichinsky EP, Neumayr LD, Gold JI, Weiner MW, Rule RR, Truran D, Kasten J, Eggleston B, Kesler K, McMahon L, Orringer EP, Harrington T, Kalinyak K. De Castro LM. Et al. (2010) Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group. Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA. 303(18):1823-31.

Steinberg MH, McCarthy WF, Castro O, Ballas SK, Armstrong FD, Smith W, Ataga K, Swerdlow P, Kutlar A, De Castro LM, Waclawiw MA, Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia and MSH Patients' Follow-Up.(2010) The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. AJH. 85(6) 403-408.

Stanton MV, Jonassaint CR, Bartholomew FB, Edwards C, Richman L, DeCastro L, Williams R. (2010) The association of optimism and perceived discrimination with health care utilization in adults with sickle cell disease.  J Nat Med Assoc. 102(11):1056-63.

Royal CD, Jonassaint CR, Jonassaint JC, De Castro LM. (2011) Living with sickle cell disease: traversing 'race' and identity. Ethnicity & Health. 16(4-5):389-404.

Shah N, Landi D, Shah R, Rothman J, De Castro LM, Thornburg CD. (2011)Complications of implantable venous access devices in patients with sickle cell disease. Am J Hematol. 87(2)224-26 PMID: 22081438

De Castro LM, Zennadi R, Jonassaint JC, Batchvarova M, Telen M J (2012), Effect of Propranolol as Antiadhesive Therapy in Sickle Cell Disease. Clinical and Translational. 5(6):437-44. PMID: 23253664

Tanabe P, Stevenson A, DeCastro L, Drawhorn L, Lanzkron S, Molokie RE, Artz N. (2013) Evaluation of a train-the-trainer workshop on sickle cell disease for ED providers.J Emerg Nurs. Nov;39(6):539-46. Epub 2011 Sep 19.

Shah N, Jonassaint JC, De Castro L.(2014). Patients with Sickle Cell Disease Welcome and Utilize the Sickle Cell Mobile Application to Record Symptoms via Technology (SMART) app. Hemoglobin 38(2):99103.

Shah N, Rollins M, Landi D, Shah R, Bae J, De Castro LM. (2014) Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis.Clin J Pain. Mar;30(3):266-8.

Elmariad H, Garrett ME, De Castro LM, Jonassaint JC, Ataga KI, Eckman JR, Ashley-Koch AE, Telen MJ. (2014) Factors Associated with Survival in a Contemporary Adult Sickle Cell Disease Cohort. Am J Hematol. 2014 May;89(5):530-5. Epub 2014 Feb 21.

Edwards CL, Killough A, Wood M, Doyle T, Feliu M, Barker CS, Uppal P, DeCastro L, Wellington C, Whitfield KE, O'Garo KG, Morgan K, Edwards Alesii LY, Byrd GS, McCabe M, Goli V, Keys A, Hill L, Collins-McNeil J, Trambadia J, Guinyard D, Muhammad M, McDonald P, Schmechel DE, Robinson E. (2014) Emotional reactions to pain predict psychological distress in adult patients with Sickle Cell Disease (SCD). Int J Psychiatry Med. ;47(1):1-16.

Klings ES, Machado RF, Barst RJ, Morris CR, Mubarak KK, Gordeuk VR, Kato GJ, Ataga KI, Gibbs JS, Castro O, Rosenzweig EB, Sood N, Hsu L, Wilson KC, Telen MJ, Decastro LM, Krishnamurti L, Steinberg MH, Badesch DB, Gladwin MT; American Thoracic Society Ad Hoc Committee on Pulmonary Hypertension of Sickle Cell Disease. (2014) An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. Am J Respir Crit Care Med. Mar 15;189(6):727-40. 

Wun T, Styles L, DeCastro L, Telen MJ, Kuypers F, Cheung A, Kramer W, Flanner H, Rhee S, Magnani JL, Thackray H. (2014) Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia. PLoS One. Jul 2;9(7):e101301.