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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Samit Ghosh, PhD

 

Samit Ghosh

 

Samit Ghosh, PhD

Research Assistant Professor of Medicine,
Division of Hematology/Ocology

E1200-8B BST
200 Lothrop Street
Pittsburgh, PA 15261

Phone: 412-648-9427
Email: sag130@pitt.edu


Ofori-Acquah Lab

Mentor: Pittsburgh Intensive Training in Hematology Research

   

Bio

Dr. Samit Ghosh is a biomedical research scientist, primarily trained in disease biology of animal model systems. Dr. Ghosh holds a PhD in Cancer Biology from Jadavpur University in India. As a research fellow in Chittaranjan National Cancer Institute in India, he investigated the preventive efficacy of dietary ingredients during carcinogenesis in animal models. During his postdoctoral training in University of Texas Health Science Center at Tyler, Dr. Ghosh made significant contributions in understanding the clearance of coagulation factors from circulation. He was the first to discover ligand binding of clotting factor FVII(a) to endothelial protein C receptor (EPCR), providing critical knowledge to improve treatment efficacy of bleeding disorders, like hemophilia. He joined Aflac Cancer and Blood Disorder Center at Emory University as a postdoctoral scientist, when he investigated pathobiology of pulmonary complications in sickle cell disease. His research involved identifying the role of extracellular heme causing acute lung injury in sickle transgenic mice. Currently he serves as a junior faculty in Heart, Lung and Blood Vascular Medicine Institute in the Department of Medicine at the University of Pittsburgh.


Research Interests

Dr. Ghosh’s research goal is to delineate a translational pathway and to design platforms to expedite repair and regenerative therapeutics for the treatment of pulmonary complications of sickle cell disease (SCD). He investigates the underlying mechanisms that lead to acute or chronic pulmonary complications of SCD. His research involves two major components of SCD. One is to determine the role of TLR4 signaling and vascular adhesion machinery in the development of Acute Chest Syndrome in SCD. The other component is to define Nrf2 regulated redox mechanisms that can be targeted therapeutically to prevent chronic disease progression leading to end organ damage in SCD. His research could provide a solid foundation identifying precision drugs for protection and/or attenuation of acute and chronic lung complications in SCD. In addition, his studies offer the potential of identifying the sub-group of SCD patients at higher risk of end-organ damage, who will be more suitable for high-risk experimental therapy


Education

PhD, Chittaranjan National Cancer Institute, Jadavpur University, India, 2005.
MSc, University of Burdwan, India, 1999.


Training

Postdoctoral Associate, University of Texas Health Science Center at Tyler, TX, 2005.
Postdoctoral Fellow, Emory University, Atlanta, GA 2008.


Publications

Green M, Akinsami I, Lin A, Banton S, Ghosh S, Chen B, Platt M, Osunkwo I, Ofori-Acquah S, Guldberg R, Barabino G (2015) Microarchitectural and mechanical characterization of the sickle bone. J Mech Behav Biomed Mater. 24(48): 220 - 228.

Manci EA, Capers PL, Archer DA, Pitts A, Ghosh S, Patrickson J, Titford ME, Ofori-Acquah S, Hibbert J (2014) High protein diet attenuates histopathologic organ damage and vascular leakage in transgenic murine model of sickle cell anemia. Exp Biol Med (Maywood). 239(8): 966 - 974.

Ghosh S, Adisa O, Chappa P, Tan F, Jackson KA, Archer DR, Ofori-Acquah SF (2013) Extracellular hemin crisis triggers acute chest syndrome in sickle mice. Journal of Clinical Investigation, 123(11): 4809 – 20.

Adisa OA, Hu Y, Ghosh S, Aryee D, Osunkwo I, Ofori-Acquah SF (2013) Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. Br J Haematol. 162(5):702-5.

Ghosh S, Tan F, Ofori-Acquah SF (2012) Spatiotemporal dysfunction of the vascular permeability barrier in transgenic mice with sickle cell disease. Anemia. 2012:582018.

Ghosh S, Tan F, Yu T, Li Y, Adisa O, Mosunjac M, Ofori-Acquah SF (2011) Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease. PLoS One. 31;6(3):e18399.

Osunkwo I, Ziegler TR, Alvarez J, McCracken C, Cherry K, Osunkwo CE, Ofori-Acquah SF, Ghosh S, Ogunbobode A, Rhodes J, Eckman JR, Dampier C, Tangpricha V (2012) High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study. Br J Haematol. 159(2): 211-5.

Hendrickson JE, Hod EA, Perry JR, Ghosh S, Chappa P, Adisa O, Kean LS, Ofori-Acquah SF, Archer DR, Spitalnik SL, Zimring JC (2012) Alloimmunization to transfused HOD red blood cells is not increasd in mice with sickle cell disease. Transfusion. 52(2):231-40.

Gopalakrishnan R, Hedner U, Ghosh S, Nayak RC, Allen TC, Pendurthi UR, Rao LV. (2011) Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa). J Thromb Haemost.  8(2):301-10.    

Tan F, Ghosh S, Mbeunkui F, Thomas R, Weiner JA, Ofori-Acquah SF. (2010) Essential role for ALCAM gene silencing in megakaryocytic differentiation of K562 cells. BMC Mol Biol.  2;11:91.

Sen P, Ghosh S, Ezban M, Pendurthi UR, Vijaya Mohan Rao L. (2010) Effect of glycoPEGylation on factor VIIa binding and internalization. Haemophilia, 16(2):339-48.

Nayak RC, Sen P, Ghosh S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV (2009) Endothelial cell protein C receptor cellular localization and trafficking. Blood, 114: 174 – 186.

Ghosh S, Sen P, Pendurthi UR, Rao LV (2008) Activity and regulation of Glycopegylated FVIIa analogs. Journal of Thrombosis Haemostasis, 6: 1525 - 1533.

Pendurthi UR, Ghosh S, Mandal SK, Rao LV (2007) Tissue factor activation: is disulfide bond switching a regulatory mechanism? Blood, 110 (12): 3900 - 3908.

Ghosh S, Pendurthi UR, Steino A, Esmon C, Rao LV (2007) Endothelial protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem, 282: 11849-57.

Ghosh S, Ezban M, Persson E, Pendurthi UR, Rao LV (2007) Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface. Journal of Thrombosis Haemostasis, 5: 336-46.

Sengupta A, Ghosh S, Das RK, Bhattacharjee S, Bhattacharya S (2006) Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. European J Cancer Prevention, 15(4): 301-305.

Ghosh S, Das, RK, Sengupta, A, Bhattacharya, S. (2005) Inhibition of azoxymethane induced aberrant crypt foci in rat by diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-s-transferase and lipid peroxidation. Biological Trace Element Research, 105(1-3): 171-85.

Sengupta A., Ghosh S, Bhattacharjee S (2005) Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. Asian Pacific J Cancer Prevention, 6(2): 118-122.

Das R K, Ghosh S, Sengupta A, Bhattacharya S (2004) Inhibition of DMBA-croton oil induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate. European J. Cancer Prevention 13: 411 - 417.

Sengupta A, Ghosh S, Das S. (2004) Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat. Cancer Letters, 208: 127 – 136.

Sengupta A, Ghosh S, Bhattacharjee S and Das S (2004) Indian food ingredients and cancer prevention – an experimental evaluation of anticarcinogenic effects of garlic in rat colon. Asian Pacific J Cancer Prevention, 5(2): 126 - 132.

De S, Chakraborty R N, Ghosh S, Sengupta A, Das S (2004) Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model. Journal of Experimental & Clinical Cancer Research 23(2): 5 – 12.

Sengupta  A, Ghosh S, Das S (2003) Tea can protect against aberrant crypt foci formation during azoxymethane induced rat colon carcinogenesis. Journal of Experimental & Clinical Cancer Research, 22(2): 185 – 191.

Sengupta A, Ghosh S, Das S(2003) Tomato and Garlic can modulate azoxymethane induced colon carcinogenesis in rat. European Journal of Cancer Prevention, 12 (3): 195 – 200.

Sengupta A, Ghosh S, Saha P, Sanyal U, Das S (2003) Components of black tea can Inhibit chemically induced colon carcinogenesis through modulation of cyclooxygenase-2 activity. Experimental Oncology, 25 (3): 170 – 175.

Sengupta A, Ghosh S, Das S (2002) Inhibition of cell proliferation and induction of apoptosis on azoxymethane induced colon carcinogenesis by black tea. Asian Pacific J Cancer Prevention, 3(1): 41-46.