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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Ling Wang, MD, PhD

 

Ling Wang, MD, PhD

 

Ling Wang, MD, PhD

Research Assistant Professor of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine

E1200-23A BST
200 Lothrop Street
Pittsburgh, PA 15261

Phone: 412-624-0465
Email: lingwang@pitt.edu


Gladwin Lab

   

Bio

Dr. Wang received her MD degree from Shanghai Medical School, Fudan University, China in 1997. After 2 years of residency in Internal Medicine, she enrolled a graduate program and got her Ph.D. degree from the same university in 2006. She came to the United States in 2003 and became a research fellow at the Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN. Her research project there focused on the cellular and molecular mechanisms of alveolar epithelium in the modulating of intra-alveolar coagulation and inflammation in acute lung injury and ARDS.


Research Interests

Dr. Wang’s research interest has focused on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury. The airway epithelium serves a primary role as a protective barrier against inhaled environmental toxins and microorganisms. Recent experimental studies suggest that the anion nitrite represents an important storage form of nitric oxide (NO) that subsequently regulates a number of very important physiological activities. Physiological concentrations of nitrite mediate cytoprotection after ischemia/reperfusion (I/R) in mammalian models of I/R in the heart, liver, brain, and kidney. The effects of nitrite on acute lung injury remain unknown and the mechanisms of the cytoprotective role of nitrite need to be fully characterized. Dr. Wang will investigate the effects of nitrite on acute lung injury by using an in-vitro lung epithelium wounding model and using different murine models of experimental acute lung injury. The effects of nitrite on the inflammation and coagulation cascade in the acute lung injury will be studied.


Key Publications

Wang L, Bastarache JA, Ware LB. The coagulation cascade in sepsis. Curr Pharm Des. 2008;14(19):1860-9.

Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Respir Cell Mol Biol. 2008 May;294(5):L874-81

Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007 Jul; 62(7):608- 16.

Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra- alveolar coagulation. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):497-503

Ware LB, Bastarache JA, Wang L. Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets? Keio J Med. 2005 Sep; 54(3):142-9.

Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp Lung Res. 2004 Jan-Feb; 30(1):31-42.

Su X, Wang L, Song Y, Bai C. Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. Intensive Care Medicine 30:133-140, 2004