UPMC HEART AND VASCULAR INSTITUTE | UNIVERSITY OF PITTSBURGH | FIND PEOPLE
VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Gladwin Laboratory

Contact

Lab phone: 412-648-3016

Lab address: E1200 Biomedical Science Tower (Starzl BST), 200 Lothrop Street, Pittsburgh, PA 15261

 

Research

Dr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease.  Since 1998, Dr. Gladwin's research has led to four scientific discoveries: 1) the nitrite anion is a circulating storage pool for NO bioactivity that regulates hypoxic vasodilation and the cellular resilience to low oxygen and ischemia; 2) a novel physiological function for hemoglobin as an electronically- and allosterically-regulated nitrite reductase; 3) the characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction; and 4) the mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension.

 

People

PRINCIPAL INVESTIGATOR
  Mark Gladwin

MARK T. GLADWIN, MD

Professor and Chair, Department of Medicine
Director, University of Pittsburgh Vascular Medicine Institute
Program Director, UPMC Heart and Vascular Institute

gladwinmt@upmc.edu | 412-648-9636

 

FACULTY
  Paola Corti

PAOLA CORTI, PhD

Research Assistant Professor, Division of PACCM

Dr. Corti is studying the function of nitrite and the globins in vertebrate metabolism and cardiac signaling and the description of the chemical biology, signaling and biological function of the globins as well as their interactions with nitrite during the embryonic development and during the regeneration of the heart after amputation.

pac47@pitt.edu | 412-624-0463 | Zebrafish Aquaria

     
  Kara Hughan

KARA HUGHAN, MD

Assistant Professor of Pediatrics, Division of Endocrinology

kara.hughan@chp.edu | 412-692-5170

   

 

  Tamir Kanias

TAMIR KANIAS, PhD

Assistant Professor of Medicine, Division of PACCM

Dr. Kanias is studying the molecular mechanisms of red blood cell hemolysis. The study examines gender and genetic variation in the propensity of red blood cells to hemolyze under diverse stressors.

tak77@pitt.edu | 412-624-5004 | Lab: 412-624-7591

   

 

  Charly Lai

YEN-CHUN (CHARLY) LAI, PhD

Research Assistant Professor of Medicine, Division of PACCM

Dr. Lai is studying the effect and the underlying mechanism of nitrite on metabolic syndrome and pulmonary venous hypertension associated with metabolic syndrome.

yel19@pitt.edu | 412-648-3037

   

 

  karin potoka

KARIN POTOKA, MD

Assistant Professor of Pediatrics, Division of Newborn Medicine

plumkc@upmc.edu | 412-624-2132

   

 

  Courtney Sparacino-Watkins

COURTNEY SPARACINO-WATKINS, PhD

Research Assistant Professor of Medicine, Division of PACCM

Dr. Sparacino-Watkins is studying the kinetic properties of nitrite reduction to nitric oxide.

cew35@pitt.edu | 412-383-5853

   

 

  Bin Sun

BIN SUN, PhD

Research Assistant Professor of Medicine, Division of PACCM

Dr. Sun studies the production and regulation of nitrite by ceruloplasmin (Cp) in macrophages, A549 and HepG2 cells by using siRNA against Cp, as well as the role of inducible nitric oxide synthase (iNOS) and myeloperoxidase (MPO) in this process.

sunb@upmc.edu | 412-648-3037

   

 

  Jesus Tejero

JESUS TEJERO, PhD

Assistant Professor of Medicine, Division of PACCM

Dr. Tejero studies the chemical and kinetic features of the reactions of nitric oxide and nitrite with hemoglobin, myoglobin, cytoglobin and neuroglobin.

jet68@pitt.edu | 412-624-2651

   

 

  Ling Wang

LING WANG, PhD

Research Assistant Professor of Medicine, Division of PACCM

Dr. Wang studies the role of sodium nitrite on lung airway epithelial cells wound healing and acute lung injury.

lingwang@pitt.edu | 412-648-3037

   

 

  qinzi xu

QINZI XU, MD

Visiting Scholar, Tongji Hospital, Wuhan, China

xuqinzi@pitt.edu | 412-980-2172

 

POSTDOCS / FELLOWS
 

ELIZABETH ROCHON, PhD

Postodoctoral Associate

err26@pitt.edu

     
  Jason Rose

JASON ROSE, MD

Fellow, PACCM

rosejj@upmc.edu | 412-692-2134

 

GRADUATE STUDENTS
  Matt Amdahl

MATTHEW AMDAHL

Graduate Student Researcher, Medical Scientist Training Program

amdahl.matthew@medstudent.pitt.edu

 

RESEARCH STAFF
 

NICOLE HELBLING

Clinical Research Coordinator

nlr8@pitt.edu | 412-692-2285

   

 

  nancy huang

XUE YIN (NANCY) HUANG

Sr. Research Specialist IV

xyhuang@pitt.edu | 412-624-0463

   

 

  Bonnie Lemster

BONNIE LEMSTER

Lab Manager

bhl4@pitt.edu | 412-648-3016

   

 

  Derek Sinchar

DEREK SINCHAR

Research Technician

djs66@pitt.edu | 412-624-7591

   

 

 

QIN TONG

Research Specialist

qit3@pitt.edu

   

 

  jianmin xue

JIANMIN XUE

Sr. Research Specialist IV

jix28@pitt.edu | 412-624-0463

 

UNDERGRADUATE STUDENTS
 

Jimmy Zhang

Student Research Assistant

jiz127@pitt.edu | 412-648-3016