UPMC HEART AND VASCULAR INSTITUTE | UNIVERSITY OF PITTSBURGH | FIND PEOPLE
VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Kato Laboratory

Contact

Lab phone: 412-624-7426

Lab address: E1200 Biomedical Science Tower (Starzl BST), 200 Lothrop Street, Pittsburgh, PA 15261

 

Research

The Kato lab investigates molecular mechanisms and clinical-translational aspects of sickle cell disease.  We are particularly interested in altered signaling in erythroid progenitor cells induced by heme-bound iron, including stimulation of placenta growth factor and consequent development of pulmonary hypertension.  We also study new treatments for sickle cell disease, and we develop new platforms and methods to study sickle cell disease.

Investigating the role of Placenta Growth Factor in erythroid differentiation and in the development of pulmonary hypertension in patients with sickle cell disease.

See also: SIckle Cell Center of Excellence


People

PRINCIPAL INVESTIGATOR
  greg kato md

GREGORY J. KATO, MD

Professor of Medicine, Division of Hematology/Oncology
Director, Adult Sickle Cell Center of Excellence

Dr. Kato is the principal investigator, a hematologist and translational researcher.  He is focused on erythroid biology and sickle cell disease.  His web page related to hematology patient care is located HERE.

katogj@upmc.edu | 412-648-3017

 

FACULTY
  maria kapetanaki

MARIA KAPETANAKI, PhD

Research Assistant Professor of Medicine, Division of PACCM
Lab Manager

Dr. Kapetanaki is a molecular biologist studying the regulation of the placenta growth factor gene in erythroid progenitor cells by heme-bound iron.  She is focused on the role of oxidant response pathways, especially the Nrf-2 transcription factor and its upstream regulators.

kapetanakimg@upmc.edu | 412-624-7426

 

POSTDOCS / FELLOWS
 

BUKOLA GBOTOSHO, PhD

Postdoctoral Associate

Dr. Gbotosho is a cell physiologist studying the molecular pathways of heme entry and response to heme-induced expression of PLGF in bone marrow cells and how PLGF mediate vascular pathophysiology of pulmonary hypertension in sickle cell mouse. She is also investigating the Nrf2 oxidant stress response pathway in sensing excess intracellular heme-bound iron in cultured erythroid cells.

otg4@pitt.edu | 412-624-7426

 

GRADUATE STUDENTS
 

ESTHER ODER

PharmD Candidate, Class of 2017, University of Pittsburgh School of Pharmacy

Project: Barriers to Determination of the Medication Possession Ratio in Clinical Research

eao24@pitt.edu | 412-624-7426