UPMC HEART AND VASCULAR INSTITUTE | UNIVERSITY OF PITTSBURGH | FIND PEOPLE
VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Kaufman Laboratory

Contact

Lab phone: 412-624-8644

Lab address: E1200 Biomedical Science Tower (Starzl BST), 200 Lothrop Street, Pittsburgh, PA 15261


We are always looking for hard-working scientists to join our team!


Research Projects

Mechanisms of mtDNA integrity and expression. We are extending our understanding of how helicases interact with specific mtDNA sequences and structures to ensure genome stability and expression. We are employing the latest genome-wide high density sequencing approaches, super-resolution microscopy, and genome editing approaches to understand how deletions are formed and development respiratory dysfunction.

TFAM function in the genome stability. We are working to understand the role of the mitochondrial transcription and packaging factor TFAM in protecting the mitochondrial genome, controlling accessibility, and establishing mtDNA copy number. This work is being further extended to understand the process of regulating TFAM to these ends. Human, animal, and cell-based models are being are being used to identify regulatory networks that might be leveraged to improve genome stability and expression.

The role of mtDNA genome stability in cardiovascular disease. We are using human patient samples and animal models of cardiopulmonary diseases to understand the role of mitochondrial genome damage and reactive oxygen species in the susceptibility or progression of disease.

 

People

PRINCIPAL INVESTIGATOR
 

BRETT A. KAUFMAN, PhD

Associate Professor of Medicine, Division of Cardiology

bkauf@pitt.edu | 412-624-8140

 

POSTDOCS AND FELLOWS
  frances belmonte

FRANCES BELMONTE, PhD

Postodoctoral Associate

belmontf@pitt.edu | 412-624-8644

   

 

 

MICOL FALABELLA, PhD

Postdoctoral Associate

micolf@pitt.edu | 412-624-8644

 

RESEARCH STAFF
 

JAMES MARTIN

Senior Laboratory Specialist

jlm366@pitt.edu | 412-624-8644

   

 

 

NIK DEDOUSIS

Research Technician

nikolasd@pitt.edu | 412-624-8644

 

GRADUATE STUDENTS
 

MAHIR YILMAZ

Medical Student

email tba | 412-624-8644

 

UNDERGRADUATE STUDENTS
 

YUEFU JIANG

Student Research Assistant

yuj19@pitt.edu | 412-624-8644

     
 

AMAL SAEED

Student Research Assistant

afs37@pitt.edu | 412-624-8644