PUBLICATIONS

Selected Publications

Pubmed link

Mora AL, Woods CR, Garcia A, Xu J, Rojas M, Speck SH, Roman J, Brigham KL, Stecenko AA. (2005) Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice. Am J Physiol Lung Cell Mol Physiol. 289(5):L711-21. (PMID: 15734789)

 

Mora AL, Torres-Gonzalez E, Rojas M, Corredor C, Ritzenthaler J, Xu J, Roman J, Brigham K, Stecenko A. (2006) Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis. Am J Respir Cell Mol Biol. 35(4):466-73. (PMID: 16709958 / PMCID: PMC2643265)

mora cover 1
Cover is based on an image showing accumulation of alveolar macrophages in fibrotic areas of MHV68-infected IFN-γR−/− mice— Masson trichrome staining from IFN-γR −/−mice at Day 180 after MHV68 infection. Mora AL. Am J  Respir Cell and Mol Biol. 35(4):466-73.

 


Mora AL, Torres-Gonzalez E, Rojas M, Xu J, Ritzenthaler J, Speck SH, Roman J, Brigham K, Stecenko A. (2007) Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice. Am J Respir Crit Care Med. 175(11):1139-50. (PMID 17363768 / PMCID PMC1899276)

mora cover 2
Cover is based on an image of Masson trichrome staining of lung section from a murine γ-herpesvirus 68 (MHV68)–infected mouse. Mora AL. Am J Respir Crit Care Med. 175(11):1139-50.

 


Pozharskaya V, Torres-Gonzalez E, Rojas M, Gal A, Amin M, Dollard S, Roman J, Stecenko AA, Mora AL. (2009) Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PLoS One. 4(10):e7559. (PMID 19851501/PMCID PMC2761603)

 

Krug LT, Torres-Gonzalez E, Qin Q, Sorescu D, Rojas M, Stecenko A, Speck SH, Mora AL. (2010) Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis. Am J Pathol. 177(2):608-21. (PMID 20566741/PMCID PMC2913377)

 

Mora AL, Rojas M. (2008) Aging and lung injury repair: a role for bone marrow derived mesenchymal stem cells. J Cell Biochem. 105(3):641-7. (PMID 18759327)

 

Torres-Gonzalez E, Bueno M, Tanaka A, Krug L, Cheng D-S, Sorescu D, Blackwell T, Rojas M, Mora AL (2012).  Endoplasmic reticulum stress in age-related susceptibility to lung fibrosis.   Am J Respir Cell Mol Biol. Jun; 46 (6). PMID: 22227563.  PMCID:  PMC3380287.

 

Bueno M, Lai Y-C, Romero Y, Brands J, StCroix C, Kamga C, Corey C, Herazo-Maya JD, Sembrant J, Lee J, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J. Clin Invest.,2015.  125(2):521-38. PMID: 25562319.

mora cover 1
Featured in JCI Impact
The cover image is a false-colored transmission electron micrograph of an alveolar type II cell from the lung of a patient with idiopathic pulmonary fibrosis. Dysmorphic, swollen mitochondria are shown in pink.

 


Lai Y-C, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov D, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT. SIRT3-AMPK activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension in heart failure with preserved ejection fraction (PH-HFpEF). Circulation. 2016. 133(8):717-31. PMID: 26813102.

 

Romero Y, Bueno M, Ramirez R, Álvarez D, Sembrat JC, Goncharova EA, Rojas M, Selman M, Mora AL, Pardo A. mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts. Aging Cell. 2016 Aug 26. doi: 10.1111/acel.12514.

 

Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD. Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor. Am J Respir Cell Mol Biol. 2017 Apr;56(4):488-496.

 

Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction. Am J Respir Cell Mol Biol. 2017 Apr;56(4):497-505.


Review Articles

Mora AL, Rojas M.  Aging and lung injury repair: a role for bone marrow derived mesenchymal stem cells.  J Cell Biochem. 2008 Oct 15; 105(3):641-7.  PMID: 18759327.​

Selman M, Rojas M, Mora AL, Pardo A. (2010) Aging and interstitial lung diseases: unraveling an old forgotten player in the pathogenesis of lung fibrosis. Semin Respir Crit Care Med. 31(5):607-17. (PMID 20941661)

Kapetanaki MG, Mora AL, and Rojas M. Influence of age on wound healing and fibrosis. J. Pathol. 2013. 229(2):310-22. PMID 231224998.

Rojas M, and Mora ALAdult stem cells for chronic lung disease. 2013.  Respirology, 18(7):1041-6. PMID 23648014.

Rojas M, Mora AL, Kapetanaki M, Weathington N, Gladwin M, Eickelberg O. Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways. Ann Am Thorac Soc. 2015 Dec;12(12):S222-7.

Mora AL, Bueno M, Rojas M. Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis. J Clin Invest. 2017 Feb 1;127(2):405-414.