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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Emilie Coppin, PhD

 

Gladwin

 

Emilie Coppin, PhD

Postdoctoral Associate

1720 BST
200 Lothrop Street
Pittsburgh, PA 15261

Lab Phone: 412- 648-8469
Email: coppine@pitt.edu


Dutta Lab

   

Bio

Dr. Coppin received her masters degree in Immunology in 2010 from Aix Marseille University, France. She succeeded to her PhD in 2015. Her PhD have been performed in the Centre de Recherche en Cancerologie de Marseille CRCM Inserm U1068 and Institut Paoli Calmettes IPC in Marseille, France under Jacques Nunes direction. Her work was supported by fellowships from the Region Provence Alpes Cote d’Azur–Innate Pharma and Fondation Association pour la Recherche sur le Cancer pour la Recherche sur le Cancer A.

Her PhD work has been subdivided in two studies focusing on Dok (Downstream of Tyrosine kinase) proteins, known as negative regulators of RAS/MAPK and AKT/PI3K signaling pathways. First she studied involvement of DOK2 point mutations in Chronical Myelomonocytic Leukemia CMML, highlighting DOK2 role as haploinsufficient tumor suppressor gene in this SMD/SMP hematological disorder. In an other hand she studied role of dok1 and dok2 in cell cycle regulation of Hematopoietic Stem and Progenitor Cells HSPC.

In 2016, she joined Dr. Partha Dutta’s lab in the Vascular Medicine Institute at the University of Pittsburgh to investigate the change Hematopoietic Stem and Progenitor Cells HSPC activation and differenciation and functions of inflammatory cells in cardiovascular diseases.


Publications

Coppin E, De Grandis M, Pandolfi PP, Arcangeli M-L, Aurrand-Lions M, and Nunes JA. Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells. Journal of Immunology, 2016 May 15; 196(10):4110-21.

Coppin E, Malergue F, Thibult ML, Scifo C, Favre C, Nunès JA. Flow cytometric analysis of intracellular phosphoproteins in human monocytes. Cytometry B Clin Cytom. 2015 Apr 23

Coppin E, Gelsi-Boyer V, Morelli X, Cervera N, Murati A, Pandolfi PP, Birnbaum D, Nunès JA. Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML). Leukemia. 2015 Feb;29(2):500-2.

Cervera N, Itzykson R, Coppin E, Prebet T, Murati A, Legall S, Vey N, Solary E, Birnbaum D, Gelsi-Boyer V. Gene mutations differently impact the prognosis of the myelodysplastic and myeloproliferative classes of chronic myelomonocytic leukemia. Am J Hematol. 2014 Jun;89(6):604-9.

Brecqueville M, Rey J, Bertucci F, Coppin E, Finetti P, Carbuccia N, Cervera N, Gelsi-Boyer V, Arnoulet C, Gisserot O, Verrot D, Slama B, Vey N, Mozziconacci MJ, Birnbaum D, Murati A. Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes Chromosomes Cancer. 2012 Aug;51(8):743-55.

Nunès JA, Firaguay G and Coppin E. Analysis of Cellular Signaling Events by Flow Cytometry. 2012, Biochemistry, Genetics and Molecular Biology  "Flow Cytometry - Recent Perspectives", book edited by Ingrid Schmid, ISBN 978-953-51-0626-5, Chapter 16 : 325-336

Sedjaï F, Acquaviva C, Chevrier V, Chauvin JP, Coppin E, Aouane A, Coulier F, Tolun A, Pierres M, Birnbaum D, Rosnet O. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. J Cell Sci. 2010 Jul 15;123(Pt 14):2521.

Peyrefitte CN, Bessaud M, Pastorino BA, Gravier P, Plumet S, Merle OL, Moltini I, Coppin E, Tock F, Daries W, Ollivier L, Pages F, Martin R, Boniface F, Tolou HJ, Grandadam M. Circulation of Chikungunya virus in Gabon, 2006-2007. J Med Virol. 2008 Mar;80(3):430-3.


Patent

Method for diagnosing myeloproliferative chronic myelomonocytic leukemia or unclassified myeloproliferative myelodysplastic neoplasm.

Coppin E, Gelsi-Boyer V, Birnbaum D, and Nunès JA.
PCT/EP2015/071457- Sep. 18, 2015. WO2016042137A1