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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Jonathan Florentin, PhD

 

Gladwin

 

Jonathan Florentin, PhD

Postdoctoral Associate

1720 BST
200 Lothrop Street
Pittsburgh, PA 15261

Lab Phone: 412- 648-8469
Email: jflor@pitt.edu


Dutta Lab

   

Bio

Dr. Florentin received his master’s degree in Human Pathology and Infectious Diseases in 2009 from the Faculty of Medicine Aix-Marseille University, France. He was awarded with the French Ministry of Research and Technology fellowship in 2009 to study the impact of Hepatitis C Virus (HCV) on a subset of cells of the innate immunity, the plasmacytoid dendritic cells (pDCs) in Dr. Ivan HIrsch lab at CRCM-INSERM (France).  In 2013, he obtained his PhD in Human Pathology and Immunology from Aix-Marseille University, France. In 2013, he joined Michael Gale Jr. lab in Seattle, WA, USA, to study the relevance of dendritic cells in the context of West Nile Virus (WNV) and Dengue Virus infections (DenV). In 2015, he joined Dr. William Burlingham’s lab at the University of Wisconsin-Madison, WI, USA to investigate the role of maternal microchimerism derived exosomes in antigen acquisition in the context of transplantation. He then joined Dr. Partha Dutta’s lab in the Vascular Medicine Institute at the University of Pittsburgh, PA, USA, to work on change in hematopoietic stem and progenitor cells and function of inflammatory cells in pulmonary hypertension.


Publications

Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, Barnes A, Florentin J, Tawar RG, Xiao F, Turek M, Durand SC, Duong FH, Heim MH, Cosset FL, Hirsch I, Samuel D, Brino L, Zeisel MB, Le Naour F, McKeating JA, Baumert TF. HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex. Cell Host Microbe. 2013 Mar 13;13(3):302-13.

Florentin, J., Aouar, B., Dental, C., Thumann, C., Firaguay, G., Gondois-Rey, F., Soumelis,V., F. Baumert, T., A. Nunès, J., Olive, D., Hirsch, I., Stranska, R.* HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. Blood 2012 Nov 29;120(23):4544-51.

Dental,C., Florentin, J., Aouar, B., Gondois-Rey, F., Durantel, D., Baumert, T. F., Nunes, J. A., Olive, D., Hirsch, I., and Stranska, R. Hepatitis C virus fails to activate NF-kappaB signaling in plasmacytoid dendritic cells. J Virol. 2012;86:1090-1096.