Congratulations to Dr. Iain Scott who was recently awarded a new NIH-NHLBI R01. Dr. Scott has been awarded annual direct costs of over $350,000 his grant titled, “Fatty acid oxidation in female cardioprotection.” This proposal was submitted in response to the competitive funding opportunity titled NIH Research Project Grant (Parent R01) under funding opportunity number PA-20-185.
Pre-menopausal women display a significantly lower incidence of cardiovascular disease than age-matched men, however this relative protection is lost after menopause. While reduced estrogen levels in post- menopausal women have been linked to this loss of protection, the biological mechanism is not fully understood. In this proposal, Dr. Scott seeks to understand whether changes in cardiac metabolism, caused by reduced estrogen levels, make the hearts of post-menopausal women more susceptible to injury and disease.