By combining computational and experimental approaches, University of Pittsburgh School of Medicine and Prairie View A&M University researchers identified cancer drugs that show promise for treating pulmonary hypertension, or PH, a rare and incurable lung disease.
Published today in Science Advances, the study used a new algorithm to identify candidate cancer drugs for PH. Two of these compounds improved markers of the disease in human cells and rodents. The findings support broader use of this drug-repurposing platform for other non-cancerous conditions that don’t yet have effective treatments.
- Cancer Drugs Could Be Used to Treat Pulmonary Hypertension
- PVAMU professor co-leads groundbreaking research in pulmonary hypertension
- Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension
- Novel Computational Pipeline Could Help Repurpose Cancer Drugs
- Algorithm identifies cancer drugs to treat pulmonary hypertension
- New computing pipeline could help repurpose cancer drugs to treat rare diseases
- Anti-cancer drugs show promise for pulmonary hypertension and other rare diseases
- Could cancer drugs address a hard-to-treat lung disease? Researchers say 2 look promising
Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, Sharifi-Sanjani M, Rajaratnam A, Sembrat J, Provencher S, Yin X, Vargas SO, Rojas M, Bonnet S, Torrino S, Wagner BK, Schreiber SL, Dai M, Bertero T, Al Ghouleh I*, Kim S*, Chan SY*. Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension. Sci Adv. 2021 Oct 22;7(43):eabh3794. doi: 10.1126/sciadv.abh3794. Epub 2021 Oct 20. PMID: 34669463; PMCID: PMC8528428.
*Co-senior authors, equal contribution