Addressing unproven theories spanning for more than a decade, we demonstrate that specific pieces of genetic material called microRNAs are transported from the blood into the lining of blood vessels of the lung to promote a deadly disease called pulmonary hypertension.
Zhao J, Florentin J, Tai YY, Torrino S, Ohayon L, Brzoska T, Tang Y, Yang J, Negi V, Woodcock CC, Risbano MG, Nouraie SM, Sundd P, Bertero T, Dutta P, Chan SY. Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension. Circ Res. 2020 Aug 14;127(5):677-692. doi: 10.1161/CIRCRESAHA.119.316398. Epub 2020 Jun 4. PMID: 32493166; PMCID: PMC7429300.
In this issue Zhao et al uses #parabiosis of the circulatory systems to demonstrate that #miR210 originating from the #blood localizes to #lung #endothelium and promotes #Pulmonary Hypertension https://t.co/feCrX42kkm— Circulation Research (@CircRes) August 21, 2020
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