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Office Location
BST E1240

Lab Location
BST 1702

Email: chansy@pitt.edu

Phone: 412-383-6990

Assistant:
 Erica Carson   carsonec@upmc.edu

Laboratory Website

Department of Medicine Profile

UPMC Profile

Twitter @chansteve73

Stephen Y. Chan, MD, PhD, FAHA

Professor of Medicine, Division of Cardiology
Vitalant Chair in Vascular Medicine
Director, Vascular Medicine Institute
Director, Center for Pulmonary Vascular Biology and Medicine
Associate Chief of Cardiology, Basic Science

Bio

Dr. Chan is a Professor of Medicine and Director of the Vascular Medicine Institute at the University of Pittsburgh. He also directs the Center for Pulmonary Vascular Biology and Medicine with an intent to bridge systems-level molecular insight to precision medicine in PH. Dr. Chan has published >100 peer-reviewed publications, including seminal senior authored discoveries in PH. He has carried grants as PI, including NIH R-level and U-level grants as well as the AHA Established Investigator Award. Dr. Chan is an elected Fellow of the AHA and ASCI; serves on the AHA 3CPR Council Leadership Committee and is Chair of the NIH RIBT study section.

Research Interests

As a physician-scientist and cardiologist, Dr. Chan has devoted his career to leading a basic and translational research program and clinical center investigating the mechanisms of pulmonary hypertension (PH). Dr. Chan uses computational theory to study gene network architecture and couple these insights with unique experimental reagents derived from genetically altered rodent and human subjects. His work was among the first (1) to introduce -omics-wide discovery in PH focusing on vascular mechanosignaling; (2) to identify the network biology of non-coding RNAs in PH; (3) to define the regulation of mitochondrial and metabolic dysfunction in PH; and (4) to clarify the regulation of inflammatory cell recruitment to pulmonary vessels.

Keywords

pulmonary hypertension; metabolism; hypoxia; endothelial cells; systems biology; vascular stiffness; translational biology

Education and Training

BS, Biology, Massachusetts Institute of Technology, Cambridge, MA (MIT), 06/1995
PhD, Biomedical Sciences, University of California, San Francisco, CA (UCSF), 06/2001
MD, Medicine, University of California, San Francisco, CA (UCSF), 06/2003

Internship and Residency in Internal Medicine; Department of Medicine, Brigham and Women’s Hospital (BWH), 06/2003-06/2005

Clinical and Research Fellow in Medicine; Harvard Medical School; Division of Cardiology, Department of Medicine; Massachusetts General Hospital, 07/2005-06/2009

Selected/Representative Publications

For a complete bibliography, click here.

View Selected Papers
  • Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman J, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY (Senior Author). BOLA3 deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension. Circulation. 2019. 139:2238-2255. PMID:30759996. PMCID: PMC6519484.