Stephen Y. Chan, MD, PhD, FAHA
Professor of Medicine, Division of Cardiology
Vitalant Chair in Vascular Medicine
Director, Vascular Medicine Institute
Director, Center for Pulmonary Vascular Biology and Medicine
Associate Chief of Cardiology, Basic Science
Dr. Chan is a Professor of Medicine and Director of the Vascular Medicine Institute at the University of Pittsburgh. He also directs the Center for Pulmonary Vascular Biology and Medicine with an intent to bridge systems-level molecular insight to precision medicine in PH. Dr. Chan has published >100 peer-reviewed publications, including seminal senior authored discoveries in PH. He has carried grants as PI, including NIH R-level and U-level grants as well as the AHA Established Investigator Award. Dr. Chan is an elected Fellow of the AHA and ASCI; serves on the AHA 3CPR Council Leadership Committee and is Chair of the NIH RIBT study section.
Education and Training
BS, Biology, Massachusetts Institute of Technology, Cambridge, MA (MIT), 06/1995
PhD, Biomedical Sciences, University of California, San Francisco, CA (UCSF), 06/2001
MD, Medicine, University of California, San Francisco, CA (UCSF), 06/2003
Clinical and Research Fellow in Medicine; Harvard Medical School; Division of Cardiology, Department of Medicine; Massachusetts General Hospital, 07/2005-06/2009
For a complete bibliography, click here.
View Selected Papers
- Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009; 10 (4); 273 – 284. PMCID: PMC2759401.
- Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan III J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY (Senior Author). Vascular Stiffness Mechanoactivates YAP/TAZ-Dependent Glutaminolysis to Drive Pulmonary Hypertension. J Clin Invest. 2016; 126(9):3313-3335. PMCID: PMC5004943.
- Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman J, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY (Senior Author). BOLA3 deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension. Circulation. 2019. 139:2238-2255. PMID:30759996. PMCID: PMC6519484.
- Zhao J, Florentin J, Tai YY, Torrino, S, Ohayon L, Brzoska T, Tang Y, Yang J, Negi V, Woodcock CC, Risbano MG, Nouraie SM, Sundd P, Bertero T, Dutta P, Chan SY (Senior Author). Long range endocrine delivery of circulating miR-210 to endothelium promotes pulmonary hypertension. Circ Res. 2020. 127(5):677-692. PMID: 32493166. PMCID: PMC7429300.
- Pi H, Kosanovich CM, Handen A, Tao M, Visina J, Vanspeybroeck G, Simon MA, Risbano MG, Desai A, Mathier MA, Rivera-Lebron BN, Nguyen Q, Kliner J, Nouraie M, Chan SY (Senior Author). Outcomes of Pulmonary Arterial Hypertension are Improved in a Specialty Care Center. Chest. 2020. pii: S0012-3692(20)30334-2. PMID: 32109446. PMCID Journal – In process.