Founder, Vascular Medicine Institute
Jack D. Myers Professor and Chair, Department of Medicine
Division of Pulmonary, Allergy and Critical Care Medicine
Associate Dean for Physician-Scientist Mentoring, School of Medicine
Associate Vice Chancellor for Science Strategy

Research Interests

These investigations form the backbone of Dr. Gladwin’s current work in the Department of Medicine:

• The discovery that the nitrite anion is a circulating storage pool for NO bioactivity (Gladwin, et al. PNAS 2000) that regulates hypoxic vasodilation (Cosby Nature Medicine 2003) and the cellular resilience to low oxygen and ischemia (Duranski JCI 2005).
• The discovery of a novel physiological function for hemoglobin as an electronically and allosterically-regulated nitrite reductase (Cosby, et al. Nature Medicine 2003; Huang et al. JCI 2005).
• The characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction (Reiter, et al. Nature Medicine 2002; Morris et al. JAMA 2005; Minneci et al. JCI 2005; Rother et al. JAMA 2005).
• The mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension (Gladwin, et al. NEJM 2004).

Keywords

Pulmonary Hypertension, Sickle Cell Disease, Nitrite Therapeutics

Education and Training

Internship, Residency, Oregon Health Sciences University, 1994
Chief Resident, Oregon Health Sciences University, 1995
Critical Care Fellow, Warren G. Magnuson Clinical Center, NIH, 1996
Pulmonary-Critical Care Fellow, University of Washington, 1998

Selected/Representative Publications

For a complete bibliography, click here.