Charles McTiernan, PhD
Research Associate Professor of Medicine, Division of Cardiology
My laboratory studies the molecular basis of cardiac remodeling in heart failure, for which employ a variety of cardiac function, cellular, molecular biology, and microscopic techniques. Our publications have appeared in Circulation Research, Circulation, Journal of the American College of Cardiology, Cardiovascular Research, and PNAS, among others. To date my research has covered 4 areas;
- Proinflammatory cytokines in heart failure We demonstrated that transgenic overexpression of TNF generated a heart failure phenotype resembling that observed in human heart failure. Additional studies examined TNF effects on fibrosis and calcium handling.
- TIMPs and MMPs in cardiac remodeling We reported that a) altered expression of TIMPs and MMPs occurs in failing human hearts, b) is responsive to mechanical unloading by ventricular assist devices, c) MMP-inhibition limits cardiac remodeling in a murine heart failure model, and d) the profile of TIMP and MMP expression varies with heart failure progression.
Education and Training
BA, College of the Holy Cross, 1975
Postdoctoral training, Case Western Reserve University, 1987
For a complete bibliography, click here.