Iain Scott, PhD

Office Location
BST E1254

Lab Location
BST E1200

Email: scotti2@upmc.edu

Phone: 412-648-7691

Assistant:
Erica Carson carsonec@upmc.edu

Laboratory Website

Center for Metabolism and Mitochondrial Medicine (C3M)

Department of Medicine Profile

Twitter @matrixule

Associate Professor of Medicine, Division of Cardiology
Co-Director, Postdoctoral Training Program in Vascular Medicine

Bio

Dr. Iain Scott received his PhD in 2006 from the University of St. Andrews (UK), for research on the machinery regulating mitochondrial morphology and dynamics. He then moved to the National Institutes of Health in Bethesda MD, where he worked on apoptosis, mitochondrial metabolism, and lysine acetylation. Dr. Scott joined the University of Pittsburgh School of Medicine as an Assistant Professor of Medicine in the Division of Cardiology in August 2014, and was promoted to Associate Professor of Medicine with Tenure in June 2020.

Research Interests

The Scott laboratory aims to better understand the role played by mitochondrial dysfunction in the development of metabolic diseases. Using in vivo and ex vivo models, we examine how changes in mitochondrial energy metabolism promote the development of organ dysfunction in diabetes, ischemia, and heart failure.

Keywords

mitochondrial bioenergetics and metabolism

Education and Training

BSc, University of St Andrews, 2002
PhD, University of St Andrews, 2006

Postdoctoral Fellow, NINDS, 2006-2009
Research Fellow, NHLBI, 2009-2014

Selected/Representative Publications

For a complete bibliography, click here.

View Selected Papers

Thapa D, Manning JR, Stoner MW, Zhang M, Xie B, Scott I. Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet. Sci Rep. 2020 Jun 30;10(1):10665. doi: 10.1038/s41598-020-67812-x. PMID: 32606301; PMCID: PMC7326908.

Manning JR, Thapa D, Zhang M, Stoner MW, Traba J, McTiernan CF, Corey C, Shiva S, Sack MN, Scott I. Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury. J Mol Cell Cardiol. 2019 Apr;129:69-78. doi: 10.1016/j.yjmcc.2019.02.009. Epub 2019 Feb 15. PMID: 30776374; PMCID: PMC6486843.

Thapa D, Xie B, Zhang M, Stoner MW, Manning JR, Huckestein BR, Edmunds LR, Mullett SJ, McTiernan CF, Wendell SG, Jurczak MJ, Scott I. Adropin treatment restores cardiac glucose oxidation in pre-diabetic obese mice. J Mol Cell Cardiol. 2019 Apr;129:174-178. doi: 10.1016/j.yjmcc.2019.02.012. Epub 2019 Feb 26. PMID: 30822408; PMCID: PMC6486841.

Thapa D, Wu K, Stoner MW, Xie B, Zhang M, Manning JR, Lu Z, Li JH, Chen Y, Gucek M, Playford MP, Mehta NN, Harmon D, O’Doherty RM, Jurczak MJ, Sack MN, Scott I. The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA. J Biol Chem. 2018 Nov 16;293(46):17676-17684. doi: 10.1074/jbc.AC118.005462. Epub 2018 Oct 15. PMID: 30323061; PMCID: PMC6240879.

Thapa D, Stoner MW, Zhang M, Xie B, Manning JR, Guimaraes D, Shiva S, Jurczak MJ, Scott I. Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway. Redox Biol. 2018 Sep;18:25-32. doi: 10.1016/j.redox.2018.06.003. Epub 2018 Jun 9. PMID: 29909017; PMCID: PMC6008287.

Laboratory

Visit Dr. Name’s laboratory at vmi.pitt.edu/research/labs/scott/.

View Lab Members

Michael Stoner, Lab Manager, stonmw@upmc.edu
Janet Manning, Research Assistant Professor, manningj@pitt.edu
Dharendra Thapa, Postdoctoral Fellow, thapad@pitt.edu
Paramesha Bugga, Postdoctoral Fellow, buggap@pitt.edu
Bellina Mushala, Graduate Student, bem111@pitt.edu