Cynthia St Hilaire, PhD
The St. Hilaire lab research program stems from the previous discovery of the genetic disease Arterial Calcification due to Deficiency of CD73 (ACDC), which identified a novel role for the enzyme CD73, and its substrate adenosine, in vascular calcification and vascular remodeling. Moving forward research in the St. Hilaire lab will explore the role of CD73 and adenosine signaling in more complex vascular pathologies such as atherosclerosis, calcific aortic valve disease, and aneurysms using in vitro (primary human and mouse cells and patient-specific induced-pluripotent stem cells) and in vivo (genetically defined murine models and surgical manipulations), with the goal of translating findings in ACDC to more common vascular diseases and pathologies.
Vascular calcification and vessel remodeling
Education and Training
Postdoctoral Fellow – Vascular Biology, National Heart, Lung, and Blood Institute, 2015
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