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Office Location
BST E1200

Lab Location
Gladwin Lab / BST E1200

Email: lingwang@pitt.edu

Phone: 412-624-0465

Ling Wang, MD, PhD

Research Assistant Professor of Medicine
Division of Pulmonary, Allergy and Critical Care Medicine

Bio

Dr. Wang received her MD degree from Shanghai Medical School, Fudan University, China in 1997. After 2 years of residency in Internal Medicine, she enrolled a graduate program and got her Ph.D. degree from the same university in 2006. She came to the United States in 2003 and became a research fellow at the Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN. Her research project there focused on the cellular and molecular mechanisms of alveolar epithelium in the modulating of intra-alveolar coagulation and inflammation in acute lung injury and ARDS.

Research Interests

Dr. Wang’s research interest has focused on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury. The airway epithelium serves a primary role as a protective barrier against inhaled environmental toxins and microorganisms. Recent experimental studies suggest that the anion nitrite represents an important storage form of nitric oxide (NO) that subsequently regulates a number of very important physiological activities. Physiological concentrations of nitrite mediate cytoprotection after ischemia/reperfusion (I/R) in mammalian models of I/R in the heart, liver, brain, and kidney. The effects of nitrite on acute lung injury remain unknown and the mechanisms of the cytoprotective role of nitrite need to be fully characterized. Dr. Wang will investigate the effects of nitrite on acute lung injury by using an in-vitro lung epithelium wounding model and using different murine models of experimental acute lung injury. The effects of nitrite on the inflammation and coagulation cascade in the acute lung injury will be studied.

Keywords

nitrite and nitric oxide signaling pathway, carbon monoxide

Education and Training

MD, Shanghai Medical School, Fudan University
PhD, Shanghai Medical School, Fudan University

Postdoctoral Research Fellow, Pulmonary, Allergy and CCM, Vanderbilt University, 2008
Postdoctoral Associate, Vascular Medicine Institute, University of Pittsburgh, 2010

Selected/Representative Publications

For a complete bibliography, click here.