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Laboratories

Al Ghouleh Lab

Imad Al Ghouleh, PhD

Dr. Al Ghouleh’s lab is focused on the study of pulmonary hypertension, with a major focus on defining the mechanisms that underlie right ventricular phenotypic changes in this disease.

Lab phone: 412-624-4114
Lab location: 1704 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/al-ghouleh/

Becker Lab

Jason R. Becker, MD

The Becker Lab studies genetic and acquired cardiomyopathies in an effort to identify novel methods to prevent and treat hypertrophic cardiomyopathy and heart failure. We utilize a variety of experimental systems which include mouse, zebrafish, iPSC-cardiomyocytes and human tissue samples.

Lab phone: 412-648-2358
Lab Location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: beckerlab.pitt.edu

Chan Lab

Stephen Y. Chan, MD, PhD

Dr Chan’s lab studies the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH). Ongoing projects include: 1) Defining the network biology of non-coding RNAs in pulmonary hypertension, 2) Studying the molecular regulation of mitochondrial metabolism by microRNAs, and 3) Defining the regulation of circulating microRNAs in hypoxia and exercise.

Lab phone: 412-648-2094
Lab location: 1702 Biomedical Science Tower (Starzl BST)
Lab website: sychanlab.pitt.edu

Dutta Lab

Partha Dutta, DVM, PhD

Dr. Dutta’s laboratory studies 1) the role of inflammation in cardiovascular diseases, and 2) activation of hematopoietic stem cells after myocardial infarction.

Lab phone: 412-383-7277
Lab location: 1720 Biomedical Science Tower (Starzl BST)
Lab website: duttalab.pitt.edu

Ghosh Lab

Samit Ghosh, PhD

Dr. Ghosh’s research aims to delineate the cellular and molecular mechanisms of kidney diseases, ranging from acute kidney injury (AKI) to chronic kidney disease (CKD) and end-stage renal disease (ESRD).

Lab phone: 412-624-4574
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/ghosh-lab/

Gomez Lab

Delphine Gomez, PhD

The Gomez lab is focused on studying the functional role of epigenetic and transcriptional mechanisms in controlling key properties of vascular smooth muscle cells (SMC) including cell differentiation, lineage memory and plasticity in the context of major cardiovascular diseases including atherosclerosis.

Lab phone: 412-383-3269
Lab location: 1723 Biomedical Science Tower (Starzl BST)
Lab website: gomezlab.pitt.edu

Kaufman Lab

Brett A. Kaufman, PhD

The major research goals of the Kaufman Lab are 1) to define the biochemical events responsible for the maintenance of mtDNA content, 2) to understand how distinct pathways influence mtDNA maintenance, and 3) to understand mechanisms of mtDNA damage and resistance to damage in the context of disease.

Lab phone: 412-624-8644
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: kaufmanlab-pitt.org

Novelli Lab

Enrico M. Novelli, MD, MS

The Novelli Lab focuses on elucidating the fundamental mechanisms underlying hemolysis-associated thrombosis and vascular dysfunction in Sickle Cell Disease.

Lab phone: 412-648-3187
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/novelli/

Ofori-Acquah Lab

Solomon F. Ofori-Acquah, PhD

The Ofori-Acquah laboratory studies the role and mechanism of hemin in endothelial barrier regulation and in the pathobiology of sickle cell disease.

Lab phone: 412-648-9427
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/ofori-acquah/

Pagano Lab

Patrick J. Pagano, PhD

The overall goal of Dr. Pagano’s laboratory is to investigate the role of NADPH oxidase in normal cellular function as well as under a variety of pathophysiological conditions.

Lab phone: 412-648-2610/412-648-3640
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: paganolab.pitt.edu

Scott Lab

Iain Scott, PhD

Dr. Scott’s work focuses on the intrinsic mechanisms that regulate mitochondrial protein acetylation, and how this fundamental alteration affects organelle function at the cellular and tissue level.

Lab phone: 412-648-8018
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/scott/

Shiva Lab

Sruti S. Shiva, PhD

The overarching goal of the Shiva laboratory is to determine the molecular mechanisms by which reactive oxygen and nitrogen species regulate mitochondrial function and mediate signaling through the mitochondria, particularly in conditions of both physiological hypoxia and pathological ischemia/reperfusion.

Lab phone: 412-624-0462
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/shiva/

St Hilaire Lab

Cynthia St. Hilaire, PhD, FAHA

Dr. St. Hilaire’s research aims to characterize novel mechanisms regulating vascular calcification and vessel remodeling, and incorporates cell biology, signal transduction, and in vivo models. Particular research angles include the role of mechanical stress, extracellular matrix remodeling, and cellular stress response, in a variety of vascular disease contexts.

Lab phone: 412-648-9441
Lab location: 1744 Biomedical Science Tower (Starzl BST)
Lab website: sthilairelab.pitt.edu

Straub Lab

Adam C. Straub, PhD

The Straub laboratory investigates redox-controlled cell signaling mechanisms that regulate endothelial and smooth muscle biology of the microcirculation in the setting of both physiology and cardiovascular disease.

Lab phone: 412-648-9921
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: straublab.pitt.edu

Sundd Lab

Prithu Sundd, PhD

Dr. Sundd’s research focuses on the mechanisms of leukocyte rolling and arrest during inflammation; the role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome; and identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood.

Lab Phone: 412-648-9987
Lab Location: E1200 Biomedical Science Tower (Starzl BST)
Lab Website: sunddlab.pitt.edu

Tejero Lab

Jesus Tejero, PhD

Dr. Tejero’s research is focused on the biology of heme proteins. His main research goals include: i) to understand and characterize the chemical and kinetic features of the reactions of nitrite with hemoglobin, myoglobin, cytoglobin and neuroglobin, ii) to elucidate the cytoprotective mechanisms of the six-coordinate globins neuroglobin and cytoglobin, and iii) the development of heme-based antidotes for carbon monoxide poisoning.

Lab phone: 412-624-2651
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: vmi.pitt.edu/research/labs/tejero/

Wu Lab

Haodi Wu, PhD

The main research interests in the Wu Lab are to understand the molecular mechanisms underlying the development, disease, and senescence of heart cells, and to develop potential therapeutic strategies to rectify pathogenesis and aging in the heart. We utilize human induced pluripotent stem cell (iPSCs) platform and cutting-edge molecular, cellular, and physiological technologies to study the biology of heart cells in health and diseases, and to discover novel drugs and approaches for translational applications.

Lab phone: 412-383-1088
Lab location: E1200 Biomedical Science Tower (Starzl BST)
Lab website: wulab.pitt.edu