Principal Investigator: Samit Ghosh, PhD
Lab phone: 412-624-4574
Lab address: E1200 Biomedical Science Tower (Starzl BST)
Sickle Cell Disease (SCD) is one of the most common rare genetic disorders affecting 20-25 million people worldwide with progressive multiorgan complications leading to early mortality. The kidney is one of the most severely affected organs in SCD. Dr. Ghosh’s research aims to delineate the cellular and molecular mechanisms of kidney diseases, ranging from acute kidney injury (AKI) to chronic kidney disease (CKD) and end-stage renal disease (ESRD). His research involves two major components. One is to determine the role of circulating hemolytic byproducts, such as, heme and its scavenger proteins, hemopexin and alpha-1-microglobulin, promoting development of AKI. The other is to delineate the role of renal microvascular endothelium and tubular epithelium instigating AKI-to-CKD transition in SCD. His research interests also include the pathophysiological interactions of kidney injuries with other comorbidities in SCD. His goal is to identify prophylactic and therapeutic targets in preclinical settings with translational capabilities, and to provide new biomarkers for better prognostication and risk assessment for SCD complications.