Gladwin Lab

Laboratories

Research

Principal Investigator: Mark Gladwin, MD

Contact

Lab phone: 412-648-3016
Lab address: E1200 Biomedical Science Tower (Starzl BST)

Research

Dr. Gladwin’s clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease. Since 1998, Dr. Gladwin’s research has led to four scientific discoveries: 1) the nitrite anion is a circulating storage pool for NO bioactivity that regulates hypoxic vasodilation and the cellular resilience to low oxygen and ischemia; 2) a novel physiological function for hemoglobin as an electronically- and allosterically-regulated nitrite reductase; 3) the characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction; and 4) the mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension.

See also: Tejero Lab; Globin Solutions

Lab Members

Mark Gladwin, MD

Principal Investigator

Professor and Chair
Medicine-PACCM
gladwinmt@upmc.edu
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Paola Corti, PhD

Assistant Professor
Medicine-Cardiology
pac47@pitt.edu
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Research

Dr. Corti is studying the function of nitrite and the globins in vertebrate metabolism and cardiac signaling and the description of the chemical biology, signaling and biological function of the globins as well as their interactions with nitrite during the embryonic development and during the regeneration of the heart after amputation.