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Benign Hematology and Transfusion Medicine

The Section of Benign Hematology  (Department of Medicine, Division of Hematology/Oncology) has 9 clinical Faculty members active in clinical and basic/translational research. This group represents one of the largest benign hematology programs in the U.S.

Areas of research excellence include hemophilia and bleeding disorders (Drs. Ragni, Seaman, and Machin), whose clinical and research activities are housed in the state-of-the-art Hemophilia Center of Western Pennsylvania (HCWP), which is funded by a 340B program. Another area of excellence is sickle cell disease (Drs. Novelli and De Castro). The UPMC Adult Sickle Cell Program is funded by the Pennsylvania Department of Health. In addition, blood banking and transfusion medicine benefit from a close collaboration between the Department of Pathology (Dr. Triulzi), and the Section of Benign Hematology (Dr. Kiss).

Areas of research focus in hemophilia and bleeding disorders include novel therapies and bleeding prophylaxis in bleeding disorders, gene therapy in hemophilia, inhibitor formation, bleeding disorders in women, and aging and biomarkers in von Willebrand disease.

Areas of research focus in sickle cell disease include neurocognitive dysfunction, new biomarker development, and designing and testing evidence-based mHealth tools for improving stress and pain management.

Areas of research focus in general hematology include clinical trials in thrombotic microangiopathies/thrombotic thrombocytopenic purpura (TTP) and autoimmune hemolytic anemias.

Areas of research focus in transfusion medicine include red cell storage, platelet transfusions, transfusion related acute lung injury (TRALI), transfusion associated circulatory overload (TACO), leukoreduction, and transfusion support of stem cell and solid organ transplant recipients.

Benign Hematology Clinical and Research Faculty and Programs

Vascular Biology, Platelets, and Hemostasis

Franklin Bontempo, MD

Clinical and Laboratory Hemostasis and Thrombosis

Mark Gladwin, MD

Donor genetic variations can affect hemolytic propensity and RBC storage recovery and function

Matthew Neal, MD

Hemostasis, Inflammation, Thrombosis, Trauma, and Transfusion Surgical Outcomes (HIT3S) Research Group

Margaret Ragni, MD, MPH

Novel therapies for hemophilia and Von Willebrand Disease (VWD)

Sruti Shiva, PhD

Mitochondria, Platelets, and Heme

Red Cells, Iron, and Hematopoiesis

Grant Bullock, MD, PhD

Aconitase: an iron-sensing regulator of mitochondrial oxidative metabolism and erythropoiesis

Paola Corti, PhD

Investigating the function of zebrafish globins in development and heart generation

Joseph Kiss, MD

Impact of Iron Status and Anemia in Blood Donors… Does it Matter for RBC Transfusion Therapy

Adam Straub, PhD

Mechanisms of heme redox regulation

Darrell Triulzi, MD

Anti-fibrinolytic Agents in the Management of Thrombocytopenia

Yvette Yien, PhD
Exploring the mechanisms underlying the overarching regulation of heme synthesis by mitochondrial proteins.

Sickle Cell Disease

Laura De Castro, MD, MHSc

Translation from Biology to Clinical Trials in Sickle Cell Disease

Cheryl Hillery, MD

HMGB1 and TLR4 in Sickle Cell Disease

Charles Jonassaint, PhD

Using Mobile Technology to Bridge Gaps in Sickle Cell Disease Care

Enrico Novelli, MD, MS

Novel Biomarkers in Sickle Cell Anemia

Solomon Ofori-Acquah, PhD

Extracellular heme: a prototypical erythroid DAMP molecule and effector pathogen of sickle crisis

Tirthadipa Pradhan-Sundd, PhD

Hepatic complications in Sickle Cell Disease

Prithu Sundd, PhD

Role of platelet TLR4, NLRP3-inflammasome and extracellular vesicles in sickle cell disease

Yingze Zhang, PhD

Genetic Control of Thrombospondin Transcription and Vasculopathy in Sickle Cell Disease

Phagocytes, Granulocytes, and Myelopoiesis

Partha Dutta, PhD

Hematopoiesis in Cardiovascular Disease

Janet S. Lee, MD, MS

Translation from Biology to Clinical Trials in Sickle Cell Disease


Lisa Borghesi, PhD

Role of Toll-like receptors in hematopoiesis

Learn more about Benign Hematology and Transfusion Medicine

Division of Hematology/Oncology, Section of Benign Hematology


The Hemophilia Center of Western Pennsylvania (HCWP)

UPMC Adult Sickle Cell Program

Sickle Cell Center of Excellence