News  |  Calendar  |  Positions

Pulmonary Hypertension and Pulmonary Vascular Disease

The Pulmonary Hypertension and Pulmonary Vascular Disease (PH PVD) Section of VMI is comprised of physician-scientists and research investigators conducting research in the pulmonary vasculature across the basic, translational, and clinical spectrum. The PH PVD investigators efforts have resulted in seminal fundamental discoveries of the central role of redox stress, mitochondria-derived reactive oxygen species (ROS), and systemic mitochondrial dysfunction in pulmonary vascular disease.

The PH PVD Section has a well-established unique scientific infrastructure enabling the production of novel pharmaceutical therapeutics in pulmonary vascular disease.  The PH PVD investigators seminal discoveries have resulted in the initiation of multiple human clinical trials and FDA approvals for IND drug development.

The PH PVD Section has established a career development program in pulmonary vascular disease research (anchored by several T32 programs) and established wide synergy with other divisions and departments across the University of Pittsburgh.

See our Center for Pulmonary Vascular Biology and Medicine, founded and directed by Dr. Steve Chan, to find out more about our expansive platform for seminal research. Including our robust clinical biobank of human PH plasma, cells, and tissue and patient electronic health record registry across 41 UPMC hospitals.

PH and PVD Researchers in the VMI

Imad Al Ghouleh, PhD

Molecular biology of RV failure

Stephen Chan, MD, PhD

Systems biology, non-coding RNAs in PH

Partha Dutta, DVM, PhD

Myeloid and stem cell control of inflammation in PAH

Mark Gladwin, MD

NO, nitrite, PH, metabolic syndrome and HFpEF

Michael Mathier, MD

Multi-center PH trials

Alison Morris, MD, MS

HIV-associated PAH

Patrick Pagano, PhD

NADPH oxidase signaling and oxidative stress in PAH

Michael Risbano, MD

PAH biomarkers, pulmonary vasodilation, exercise in PH

Belinda Rivera-Lebron, MD

Acute PE and CTEPH, portopulmonary PH

Sruti Shiva, PhD

Platelet mitochondria in PAH

Adam Straub, PhD

NO, redox signaling, vessel myography in PAH

Prithu Sundd, PhD

In vivo imaging and role of platelet activation in PAH

Learn more about PH and PVD

Center for Pulmonary Vascular Biology and Medicine

UPMC Pulmonary Hypertension Services