Pulmonary Hypertension and Pulmonary Vascular Disease
The Pulmonary Hypertension and Pulmonary Vascular Disease (PH PVD) Section of VMI is comprised of physician-scientists and research investigators conducting research in the pulmonary vasculature across the basic, translational, and clinical spectrum. The PH PVD investigators efforts have resulted in seminal fundamental discoveries of the central role of redox stress, mitochondria-derived reactive oxygen species (ROS), and systemic mitochondrial dysfunction in pulmonary vascular disease.
The PH PVD Section has a well-established unique scientific infrastructure enabling the production of novel pharmaceutical therapeutics in pulmonary vascular disease. The PH PVD investigators seminal discoveries have resulted in the initiation of multiple human clinical trials and FDA approvals for IND drug development.
The PH PVD Section has established a career development program in pulmonary vascular disease research (anchored by several T32 programs) and established wide synergy with other divisions and departments across the University of Pittsburgh.
See our Center for Pulmonary Vascular Biology and Medicine, founded and directed by Dr. Steve Chan, to find out more about our expansive platform for seminal research. Including our robust clinical biobank of human PH plasma, cells, and tissue and patient electronic health record registry across 41 UPMC hospitals.
PH and PVD Researchers in the VMI
Imad Al Ghouleh, PhD
Molecular biology of RV failure
Stephen Chan, MD, PhD
Systems biology, non-coding RNAs in PH
Partha Dutta, DVM, PhD
Myeloid and stem cell control of inflammation in PAH
Mark Gladwin, MD
NO, nitrite, PH, metabolic syndrome and HFpEF
Michael Mathier, MD
Multi-center PH trials
Alison Morris, MD, MS
Patrick Pagano, PhD
NADPH oxidase signaling and oxidative stress in PAH
Michael Risbano, MD
PAH biomarkers, pulmonary vasodilation, exercise in PH
Belinda Rivera-Lebron, MD
Acute PE and CTEPH, portopulmonary PH
Sruti Shiva, PhD
Platelet mitochondria in PAH
Adam Straub, PhD
NO, redox signaling, vessel myography in PAH
Prithu Sundd, PhD
In vivo imaging and role of platelet activation in PAH
Learn more about PH and PVD
Center for Pulmonary Vascular Biology and Medicine
UPMC Pulmonary Hypertension Services
See also: Translational Program Project (tPPG)