Metabolism and Mitochondrial Medicine
The Metabolism and Mitochondrial Medicine Subsection consists of several laboratories that investigate the basic mechanisms of mitochondrial processes and cellular metabolism and translate these findings to cardiovascular physiology and metabolic disease. Currently strengths in the subsection include research in mitochondrial DNA (Dr. Kaufman), mechanisms of regulation of mitochondrial functional (Dr. Chan, Dr. Finkel, Dr. Jurczak, Dr. Scott, Dr. Sparacino-Watkins, Dr. Shiva), metabolic disease (Dr. Kershaw, Dr. Steinhauser, Dr. Yechoor). These labs are highly collaborative within the subsection and throughout the university, with funding from the NIH, AHA, and industry partners. Research in this subsection spans the bed-to-bedside continuum involving studies at the organellar level, in cell and animal models, patient samples, and through clinical trials.
Metabolism and Mitochondrial Medicine Investigators
Regulation of mitochondrial function
Steve Chan, MD, PhD
microRNA regulation of metabolism in pulmonary hypertension
Toren Finkel, MD, PhD
Mitochondrial calcium signaling and fatty acid oxidation in aging
Michael Jurczak, PhD
Regulation of metabolism by parkin
Iain Scott, PhD
Mitochondrial acetylation
Courtney Sparacino-Watkins, PhD
Regulation of metabolism by the mARC enzyme
Sruti Shiva, PhD
Regulation of bioenergetics and mitochondrial redox signaling
Mitochondrial DNA
Brett Kaufman, PhD
Mechanisms of mtDNA maintenance and damage
Metabolic Disease
Michael Jurczak, PhD
Regulation of metabolism by parkin
Erin Kershaw, MD
Regulation of lipid metabolism in obesity
Matthew Steinhauser, MD
Regulation of metabolism and adipocyte fate in Type II Diabetes
Vijay Yechoor, MD
Beta cell signaling in Diabetes