Email: lhzhang@pitt.edu
BST E1148
Lab Location
BST E1113
Email: lhzhang@pitt.edu
Office Phone: 412-864-5483
Lab Phone: 412-383-0106
Assistant:
Shannon McKenzie mckenziesj@upmc.edu
Lianghui “Lucy” Zhang, MD, PhD
Research Interests
My laboratory studies lung vascular biology and immuno-pathogenesis of acute lung injury. Our research focuses on the mechanism of respiratory viral-induced lung vascular injury and signals between endothelial cells and immune cells during the innate and adaptive immune response. The SARS-CoV-2 and H1N1-induced acute lung injury models are two major animal models used in the laboratory. We are also interested in lung vascular regeneration and mechanisms of transcriptional regulation in the vasculature. By understanding the mechanisms which regulate the balance between inflammatory injury and regeneration in viral acute lung injury, we will be able to develop new therapies that minimize inflammatory injury, maximize tissue repair and reduce patient mortality.
Education and Training
MD, Medical School of Fudan University, Shanghai, China, 2003
PhD, Pharmacology, University of Rochester, NY, 2013
Postdoctoral, University of Illinois at Chicago, 2022
Selected/Representative Publications
For a complete bibliography, click here.
View Selected Papers
- Zhang L, Gao S, White Z, Dai Y, Malik AB, Rehman J. Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations. JCI Insight. 2022 Jun 8;7(11):e158079. doi: 10.1172/jci.insight.158079. PMID: 35511435; PMCID: PMC9220950.
- Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants. Nat Chem Biol. 2022 Mar;18(3):342-351. doi: 10.1038/s41589-021-00965-6. Epub 2022 Jan 19. PMID: 35046611; PMCID: PMC8885411.
- Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants. bioRxiv [Preprint]. 2021 Dec 22:2021.12.21.473668. doi: 10.1101/2021.12.21.473668. Update in: Nat Chem Biol. 2022 Mar;18(3):342-351. PMID: 34981059; PMCID: PMC8722596.
- Xiong S, Zhang L, Richner JM, Class J, Rehman J, Malik AB. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2773-2785. doi: 10.1161/ATVBAHA.121.316925. Epub 2021 Sep 9. PMID: 34496633; PMCID: PMC8545251.
- Jambusaria A, Hong Z, Zhang L, Srivastava S, Jana A, Toth PT, Dai Y, Malik AB, Rehman J. Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation. Elife. 2020 Jan 16;9:e51413. doi: 10.7554/eLife.51413. PMID: 31944177; PMCID: PMC7002042.
Laboratory
Visit Dr. Zhang’s laboratory at zhanglab.pitt.edu.
View Lab Members
Name | Title |
Kamal Bagale, PhD | Postdoctoral Associate |
Dejuanna Chan, BS | Research Technician |