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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Isenberg Laboratory

Contact

Lab phone: 412-624-0464

Lab address: E1200 Biomedical Science Tower (Starzl BST), 200 Lothrop Street, Pittsburgh, PA 15261


AVAILABLE POSITION(S): Postdoctoral Associate


Research

The focus of our lab is to study the role matrix-cellular proteins play in controlling blood flow and tissue survival. We are particularly interested in the thrombospondin-1-CD47 signaling nexus and the role it has in modulating the canonical nitric oxide (NO) pathway. Presently we are determining the role this pathway has in controlling blood pressure, arterial dilation and endogenous NO production. We are also studying the role of TSP1-CD47 in sickle cell disease, pulmonary hypertension and ischemia-reperfusion. This same pathway appears to also regulate cell survival to other severe stress including radiation and this is a new area of interest.

See also: Animal Phenotyping Core

News

   

Dec 2012: The Isenberg Lab was highlighted on the North Atlantic Vascular Biology Organization (NAVBO) website.

NAVBOweb

7 December 2012: Isenberg Lab paper chosen as AD Instruments' Paper of the Week.

 

People

PRINCIPAL INVESTIGATOR
  Jeff Isenberg

JEFFREY S. ISENBERG, MD, MPH

Associate Professor of Medicine, Division of PACCM

Currently the lab and I are working on cell signaling pathways that control cell and tissue survival to stress. Continuing interests are focused upon investigating the role TSP1, via binding the cell surface receptor CD47, has in the acute regulation of tissue perfusion, blood flow and blood pressure with a strong translational emphasis on human pathology and disease. In collaboration with other groups we are expanding this work to include effects this has on kidney and heart function.

jsi5@pitt.edu | 412-383-5424

 

POSTDOCS / FELLOWS
 

JESSICA CASSAVAUGH, MD, PhD

PGY-3 Resident, Anesthesiology

Examining the role of exogenous TSP1 to alter RBC membrane shape and Ca2+ signaling in health and disease

cassavaughjm@upmc.edu | 412-624-0464

     
 

TAKUTO CHIBA, PhD

Postdoctoral Associate

Investigating novel matricellular protein signaling interactions in renal development and injury

chibat@pitt.edu | 412-624-0464

     
  Kedar Ghimire

KEDAR GHIMIRE, PhD, MSc

Postdoctoral Associate

Investigating the role of TSP1 to promote pathologic ROS production in response to blood flow changes and also consequent to advanced age.

keg100@pitt.edu | 412-624-0464

 

RESEARCH STAFF
 

KAITLIN BOCIAN

Lab Manager

kab371@pitt.edu | 412-624-0464

 

UNDERGRADUATE STUDENTS
 

GRACE LEE

Undergraduate Student Researcher

Grace has been awarded a Brackenridge Fellowship from the Honors College of the University of Pittsburgh to investigate the degree of expression and anatomic distribution of matricellular proteins in the cerebral vasculature of Alzheimer’s Disease subjects.

gyl2@pitt.edu | 412-624-0464

     
 

JACOB MEADOWS

Undergraduate Student Researcher

Studying matricellular signaling in vasculopathy

jmm367@pitt.edu | 412-624-0464

     
 

SHIVANI PANDYA

Undergraduate Student Researcher

Shivani is investigating the metabolic changes found in the kidney and in renal tubule epithelial cells after acute injury.

sdp43@pitt.edu | 412-624-0464

 

Previous lab members:

Eileen Bauer, PhD, Assistant Professor, Department of Surgery, University of Pittsburgh School of Medicine

Kene Ukeje, Student Research Assistant, is accepted to medical school with matriculation in the fall of 2011.

Fatima Muhammed-Ighile, Student Research Assistant

Xiaojun Huang, MD, Animal Specialist

Molly Yao, PhD, Assistant Professor of Pharmacology at MidWestern University College of Pharmacy in Glendale, Arizona

Daniel Dempe, Student Research Assistant

Lisa Nagy, Student Research Assistant

George Rogers, PhD, Visiting Scholar

Maryam Sharifi-Sanjani, PhD, Postodoctoral Scholar

Raquel Bienes Martinez, PhD, Postdoctoral Associate

Drew Bradshaw, Graduate Student

David Labrousse Arias, Visiting Scholar

Eric Zhang, Undergraduate Student Researcher

Natasha Rogers, MBBS(Hons), FRACP, PhD, Awarded AHA Science Development Grant, Faculty at the University of Sydney

Caitlin Czajka, PhD, Associate Managing Editor, Science Translational Medicine

Johannes Kutten, Successfully defended his thesis “Role of TSP1-CD47 Signaling in Tracheal repair and Regeneration” August 11, 2016. After his thesis defense Johannes returned to complete his MD studies at the University of Pittsburgh School of Medicine and is expected to graduate in 2018.