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VMI
 


Vascular Medicine Institute
University of Pittsburgh
BST E1240
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-5853
Fax: 412-648-5980

Novelli Laboratory

Contact

Lab phone: 412-648-3187

Lab address: E1200 Biomedical Science Tower (Starzl BST), 200 Lothrop Street, Pittsburgh, PA 15261

 

Research

One recent interest of Dr. Novelli's is elucidating the fundamental mechanisms underlying hemolysis-associated thrombosis and vascular dysfunction in SCD.  Dr. Novelli's current research project explores the role of Thrombospondin-1 (TSP1), a glycoprotein abundantly present in platelet α-granules is emerging as a key regulator of hemostasis and thrombosis. Another research project aims at exploring the role of the interaction between TSP1 and CD47 in SCD. This project also explores the hypothesis that therapeutic disruption of the TSP1-CD47 ligand-receptor interaction will both prevent and reverse pulmonary hypertension in SCD.

See also: UPMC Adult Sickle Cell Anemia Program


People

PRINCIPAL INVESTIGATOR
  Enrico Novelli, MD, MS

ENRICO M. NOVELLI, MD, MS

Assistant Professor of Medicine, Division of Hematology/Oncology
Medical Director, UPMC Adult Sickle Cell Anemia Program
Associate Director, Hemophilia Center of Western PA

noveex@upmc.edu | 412-624-2591

 

RESEARCH STAFF
  lynda ihrig

LYNDA L. IHRIG, BS

Laboratory Specialist

ihrig3@pitt.edu | 412-648-3187